Olcay Sahin,
Molecular Biologist
Genome Dynamics & Cancer Mechanobiology
Bridging the gap between wet-lab precision and bioinformatics to decipher the molecular mechanisms of tumorigenesis, mechanotransduction, and chromatin dynamics.
About Me
I am a researcher dedicated to exploring how physical forces and nuclear architecture influence genome stability. My recent work at Strasbourg University (IGBMC & ESBS) focused on Nuclear Pore Complexes and mechanotransduction in triple-negative breast cancer cells.
With a solid foundation from Istanbul University and experience in managing GMO quality control labs, I possess a hybrid skill set. I combine advanced wet-lab techniques (Confocal Microscopy, Western Blot) with bioinformatics tools (Python, Docker, R) to solve complex biological problems ranging from plant epigenetics to human cancer dynamics.
Multidisciplinary Approach
Scientific Interests
Exploring fundamental mechanisms of disease through diverse biological lenses.
Mechanobiology
Investigating how cells sense and respond to mechanical signals (stiffness) in the tumor microenvironment.
Genome Instability
Studying Nuclear Pore Complex defects and their contribution to malignant transformation.
Bioinformatics
Leveraging Python, R, and Docker for image analysis and large-scale genomic data processing.
Plant Epigenetics
Background in retrotransposon dynamics and stress responses in agricultural crops.
Research Experience
Mechanotransduction in Breast Cancer
Investigated stiffness-induced mechanotransduction in MDA-MB-231 cells. Focused on PARP3 localization dynamics using a-Tubulin and Lamin A/C spatial markers. Optimized cell fractionation to track protein distribution across cytosolic and nuclear fractions under varying substrate stiffness (1.5 kPa to 1.5 GPa).
Breast Cancer PARP3
NPC & Genome Instability
Led projects exploring Nuclear Pore Complexes (NPC) mediated transport defects. Characterized nucleocytoplasmic transport failure as a hallmark of malignant transformation in human cancer cells. Utilized immunofluorescence and Western blotting to track NPC-related protein distribution.
Genome Instability NPC
Retrotransposon Dynamics
Explored retrotransposon-mediated genome dynamics in GM and Non-GM soybean under salinity stress. Employed IRAP-PCR to profile mobilization patterns of SIRE1 and Bagy2 elements, linking abiotic stress-induced transposition activity to large-scale genomic rearrangements.
Genomics Stress ResponseEducation & Certificates
Technical Arsenal
biotech Wet Lab Techniques
code Bioinformatics & Tools
Selected Publications
Genome organization changes in GM and non-GM soybean under salinity stress
Sahin, O., Karlik, E., Meric, S., Ari, S., & Gozukirmizi, N. (2020). Genetic Resources and Crop Evolution, 67, 1551-1566.
Read Paper open_in_newGenomic analysis of feeder soybean seeds under salinity stress
Sahin, O., Meric, S., Yalcin, D. G., & Ari, S. (2017). International Green Biotechnology Congress (Poster Presentation).
Effects of histone H3 lysine 9 inhibition on gene expression profile in tobacco
Ari, S., Tombul, N., Sahin, O., & Ebrahimi, A. (2016). FEBS Journal, 283, 337-338.
Read Paper open_in_newGet in Touch
Open to PhD opportunities and collaborative research.
olcay.sahin@ogr.iu.edu.tr
Adana, Türkiye / France